| Date | Gender | City, State | Venue | Entry Open | Entry Close | USTA Section |
| Apr 18-26 | M&W | Flushing, NY | USTA BJK National Tennis Center | Mar 1 | Apr 5 | Eastern |
| May 15-19 | M&W | Springfield, MO | Cooper Tennis Complex | Mar 1 | May 1 | Missouri Valley |
| May 17-21 | M&W | Claremont, CA | The Claremont Club | Mar 1 | May 7 | Southern California |
| May 17-22 | M&W | College Park, MD | Tennis Center at College Park | Mar 10 | May 7 | Mid-Atlantic |
| May 17-23 | M&W | Salinas, CA | Chamisal Tennis Club | Mar 1 | May 1 | Northern California |
| May 19-23 | M | West Haven, CT | Yale University Tennis Center | Mar 7 | May 7 | New England |
| May 29- Jun 4 | M&W | Bradenton, FL | IMG/Bollettieri Academies | Mar 16 | May 19 | Florida |
| Jun 1-6 | M&W | Surprise, AZ | Surprise Tennis & Racquet Complex | Mar 22 | May 21 | Southwest |
| Jun 2-6 | M&W | Waipahu, HI | Central Oahu Regional Park | Mar 3 | May 21 | Hawaii Pacific |
| Jun 3-6 | W | Boston, MA | Harvard University Tennis Center | Mar 7 | May 24 | New England |
| Jun 5-13 | M&W | Mason, OH | Lindner Family Tennis Center | Feb 1 | May 15 | Midwest |
| Jun 11-17 | M&W | West Windsor, NJ | Mercer County Tennis Facility | Apr 1 | May 20 | Middle States |
| Jun 12-16 | M&W | Norcross, GA | Racquet Club of the South | Mar 1 | May 31 | Southern |
| Jun 14-20 | M | St. Cloud, MN | St. Cloud Apollo High School | Feb 5 | Jun 1 | Northern |
| Jun 14-20 | W | St. Cloud, MN | St. Cloud Apollo High School | Feb 5 | Jun 1 | Northern |
| Jun 16-20 | M&W | Denver, CO | Gates Tennis Center | April 26 | Jun 1 | Intermountain |
| Jun 18-20 | M&W | Beaverton, OR | Tualatin Hills Tennis Center | Mar 10 | Jun 7 | Pacific Northwest |
| Jun 21-26 | M&W | Arlington, TX | Arlington Tennis Center | Mar 1 | Jun 7 | Texas |
2010 US Open National Playoffs Championships
US Open National Playoffs - Men's Championship
July 22-25 / Atlanta, GA / Atlanta Athletic Club (during the Olympus US Open Series Atlanta Tennis Championships)
US Open National Playoffs - Women's Championship
July 29-August 1 / Stanford, CA / Stanford University (during the Olympus US Open Series Bank of the West Classic)
The US Open National Playoffs is a series of tournaments that gives participants the opportunity to earn a singles wild card entry to compete in the US Open Qualifying Tournament at the USTA Billie Jean King National Tennis Center, Aug. 24-27, 2010. The 16 participating USTA Sections will run a men’s and women’s Sectional Qualifying Tournament between April 1 and July 5. Now is your shot at playing on the biggest stage in sports… the US Open